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Department of Plant Sciences

 

Biography

Andre completed a BSc degree in Molecular Biotechnology before he focused towards Computational and Systems Biology during his MSc. After graduating from Heidelberg University in 2017, he started his PhD at Cambridge where his research is investigating open questions in the evolution of B vitamin dependencies, microbial interactions as well as the role of transposable elements in algae by applying multi-omic approaches. In parallel, he is co-leader of the citizen science project PuntSeq (www.puntseq.co.uk) which is employing novel real-time DNA sequencing to monitor microbial composition of freshwater sources. Andre is a Gates Cambridge scholar and has joined the Plant Metabolism Group in 2017.

Research

Work experience

2017-2021:

  • PhD thesis, Plant Metabolism Group
    Department of Plant Sciences, University of Cambridge

2016:

  • Master thesis, Genome Organization & Function Group 
    DKFZ & BioQuant Center, Ruprecht-Karls University Heidelberg
  • Research intern, Optical Nanoscopy Group
    DKFZ & BioQuant Center, Ruprecht-Karls University Heidelberg

2015:

  • Reserach intern, Plant Metabolism Group
    Department of Plant Sciences, University of Cambridge

2014:

  • Reserach intern, Plant Metabolism Group
    Department of Plant Sciences, University of Cambridge
  • Graduate research assistant, Theoretical and Computational Chemistry Group
    IWR, Ruprecht-Karls University Heidelberg 
  • Reserach intern, Bacterial Signaling Network Group
    BioQuant/ZMBH, Ruprecht-Karls University Heidelberg
  • Research intern, Computational Oncology Group 
    DKFZ, Ruprecht-Karls University Heidelberg
  • Graduate research assistant, Bacterial Signaling Network Group
    BioQuant/ZMBH, Ruprecht-Karls University Heidelberg

2013:

  • Research intern, Bacterial Signaling Network Group
    BioQuant/ZMBH, Ruprecht-Karls University Heidelberg
  • Student assistant, Biocompatibility Laboratory
    Applications Engineering, Fresenius Medical Care St. Wendel
  • Research assistant, Theoretical and Computational Chemistry Group 
    IWR, Ruprecht-Karls University Heidelberg

 

Teaching

April - October 2015: Tutor in Physical Chemistry II 
IPMB, Ruprecht-Karls University Heidelberg

2018-2020: Demonstrator for the course "1B Cell and Developmental Biology" 
Department of Plant Sciences, University of Cambridge

 

Stipends

2018/19: Frank Smart studentship

2018: e-fellows.net scholarship

2016/17: Gates Cambridge scholarship

2016: BBSRC DTP scholarship (declined)

2016: Cambridge Trust scholarship (declined)

2016: EMBL/EMBO conference fellowship 

2014: Baden-Würtemberg scholarship

Publications

Key publications: 

Urban L*, Holzer A*Baronas JJHall MBraeuninger-Weimer PScherm MJKunz DJPerera SNMartin-Herranz DETipper ETSalter SJStammnitz MR (2021) Freshwater monitoring by nanopore sequencing. eLife 10: e61504. doi: 10.7554/eLife.61504

Bunbury FHelliwell KHMehrshahi PDavey MPSalmon DHolzer ASmirnoff NSmith AG (2020) Responses of a Newly Evolved Auxotroph of Chlamydomonas to B12 DeprivationPlant Physiology 183: 167-178. doi: 10.1104/pp.19.01375

Holzer A, Newsad S, Tran NA, Harrison E, Smith AG (2020) Microalgae, bacteria and vitamins: three key players in aquatic microbial communities. Microbiology Today

Helliwell KE, Lawrence AD, Holzer A, Kudahl UJ, Sasso S, Kräutler B, Scanlan DJ, Warren MJ & Smith AG (2016) Cyanobacteria and Eukaryotic Algae Use Different Chemical Variants of Vitamin B12. Current Biology 26: 999-1008. doi: 10.1016/j.cub.2016.02.041

* shared first author

Other publications: 

Geisler K, Scaife MA, Mordaka PM, Holzer A, Mehrshahi P, Mendoza Ochoa G, Smith AG (2021) Exploring the impact of terminators on transgene expression in Chlamydomonas reinhadrtii with a synthetic biology approachBioRxiv preprint . doi: 10.1101/2021.08.04.455025

Urban L*, Holzer A*Baronas JJHall MBraeuninger-Weimer PScherm MJKunz DJPerera SNMartin-Herranz DETipper ETSalter SJStammnitz MR (2020) Freshwater monitoring by nanopore sequencing. BioRxiv preprint 1-38. doi: 10.1101/2020.02.06.936302

Bunbury FHelliwell KHMehrshahi PDavey MPSalmon DHolzer ASmirnoff NSmith AG (2019) Physiological and molecular responses of a newly evolved auxotroph of Chlamydomonas to B12 deprivationBioRxiv preprint 1-20. doi: 10.1101/836635

Holzer A (2019). The Chlamydomonas reference genomes for visualisation in IGV (Version v1.0)Zenodo. doi: 10.5281/ZENODO.3732212

Holzer A, Urban L, Stammnitz M (2019). Health and the River Cam, Public Survey AnalysisZenodo. doi: 10.5281/ZENODO.3823356

Wenzel J, Holzer A, Wormit M & Dreuw A (2015) Analysis and comparison of CVS-ADC approaches up to third order for the calcula on of core-excited states. The Journal of Chemical Physics 142: 214104. doi: 10.1063/1.4921841.

Postgraduate Student
Mr Andre  Holzer

Contact Details

Email address: 
Department of Plant Sciences,
University of Cambridge,
Downing Street,
Cambridge,
CB2 3EA
01223 330219