Synthetic Biology is an emerging field that employs engineering principles for constructing genetic systems. The approach is based on the use of well characterised and reusable components, and numerical models for the design of biological circuits.
We have constructed a series of tools for controlling gene misexpression and marking specific cells in growing plants. We are building a new generation of genetic circuits that incorporate intercellular communication, and could be used to generate self-organised behaviour at the cellular scale. These can be used to reprogram plant development and morphogenesis. We have chosen Marchantia polymorpha as a simple model system for understanding and engineering plant growth. This lower plant provides unparalleled benefits in ease of culture, simple genome, haploid genetics, open form of development and rapid growth and regeneration, and is an ideal partner for modern quantitative analytical tools.
Synthetic and Engineering Biology initiatives in Cambridge
The laboratory helps to organise a range of Synthetic and Engineering Biology themed initiatives that promote interdisciplinary exchange between Biology, Computer Sciences and Engineering in Cambridge though informal meet-ups, forums, project-based training and shared research projects.