skip to primary navigationskip to content

Research Associate (Fixed Term) - Henderson group

The increasing demand for food, in the context of a changing climate and deteriorating environments, will be one of the major challenges facing society in the coming decades. To strengthen global food security plant scientists and breeding companies seek to develop new crop varieties that produce a higher yield in harsher and changing environments. We have identified the gene HEI10, which encodes a conserved meiotic ubiquitin E3 ligase, as a major regulator of crossover numbers (Ziolkowski et al., 2016 Genes & Dev). For example, we have found that natural genetic polymorphisms in HEI10 are strongly associated with quantitative variation in crossover frequency between Arabidopsis populations. Importantly, during this work we discovered that HEI10 is highly dosage-sensitive and introduction of additional copies of this genes more than doubled crossovers throughout the Arabidopsis chromosome arms. The proof of concept idea to be developed in this project is to increase HEI10 copy number in bread wheat to elevate recombination frequency and thereby accelerate breeding. Crossover frequency is particularly limiting in the extremely large, hexaploid bread wheat genome, which is one of our most important crops.

You will be based in the Henderson group in central Cambridge. The successful applicant should have a Ph.D. in a relevant area of genetics or genomics. Experience of plant and crop genetics is an advantage. Techniques relevant to the proposed work include genetics, molecular biology, transformation and immunocytological analysis of meiosis. The applicant should posses a high degree of creativity and self-motivation. In addition they should be comfortable working both independently and as part of a team. They require good communication skills and the ability to convey the importance of their research to both other specialists, in addition to a general audience.

  • Salary: £31,604-£38,833
  • Fixed-term: The funds for this post are available for 1 years in the first instance.
  • Closing date: 19 February 2018
  • Download: Further details
  • You can apply online for this vacancy. You will need to register an account (if you have not already) and log in before completing the online application form.
  • Please upload a cover letter and CV to support your application.
  • Please quote reference PD14606 on your application and in any correspondence about this vacancy.

Please note if you have not received any news from us 1 month after the closing date you should consider that on this occasion your application has been unsuccessful.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.