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Dr Sebastian Müller

Contract Research Staff
Dr Sebastian Müller
Department of Plant Sciences
University of Cambridge
Downing Street

Cambridge CB2 3EA
Office Phone: 01223 748976

Research Interests

Much of my current research focuses on bioinformatic analysis of non-coding RNAs, particularly small RNAs such as micro-RNAs, hc-siRNAs or nat-siRNAs and its roles in RNA silencing through either direct targeting of mRNAs or through epigenetic reprogramming such as DNA methylation or Histon modification.

This is achieved by utilizing sequencing technologies such as smallRNA-Seq, ChiP-Seq, degradome-Seq and BS-Seq in particular for Arabidopsis thaliana and tomato.

Key Publications

C. Otzen, S. Müller, I. D. Jacobsen and M. Brock, ‘Phylogenetic and phenotypic characterisation of the 3-ketoacyl-CoA thiolase gene family from the opportunistic human pathogenic fungus Candida albicans‘, FEMS Yeast Res, 2013

M. S. V. Gurovic, S. Müller, N. Domin, I. Seccareccia, S. Nietzsche, K. Martin, and M. Nett, ‘Micromonospora schwarzwaldensis sp. nov., a producer of telomycin, isolated from soil in the Black Forest’, Int J Syst Evol Microbiol, May 2013.

S. Müller, C. Baldin, M. Groth, R. Guthke, O. Kniemeyer, A. A. Brakhage, and V. Valiante, ‘Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression’, BMC Genomics, vol. 13, no. 1, p. 519, Oct. 2012.

L. Tierney, J. Linde, S. Müller, S. Brunke, B. Hube, R. Guthke, and K. Kuchler, ‘An interspecies regulatory network inferred from simultaneous RNA-seq of Candida albicans invading innate immune cells’, Frontiers in Microbial Immunology, vol. 3, p. 85, 2012.

S. Kastner*, S. Müller*, L. Natesan, G. M. König, R. Guthke, and M. Nett, ‘4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence’, Archives of Microbiology, Feb. 2012.

S. Müller, C. B. Fleck, D. Wilson, C. Hummert, B. Hube, and M. Brock, ‘Gene acquisition, duplication and metabolic specification: the evolution of fungal methylisocitrate lyases’, Environmental Microbiology, vol. 13, no. 6, pp. 1534–1548, Jun. 2011.

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