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RNA silencing networks

rna networks
A representation of networks in which siRNAs and miRNAs are represented as red symbols and their precursors and targets as blue or yellow symbols. Such networks could be used by the cell to integrate the expression of many genes.
Long RNA molecules that are targeted by an siRNA-guided Argonaute protein may be degraded or translationally suppressed. They may also be stimulated to become a source of secondary siRNAs. The secondary siRNAs may also guide Argonaute proteins and stimulate further rounds of siRNA production. We are using computer modelling approaches to investigate the potential for these cascades or networks of siRNA and miRNA and we will follow up this analysis with experimental testing of the predicted networks.