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Webb Group: Dynamic plasticity of the circadian clock


Supervisor: Alex Webb (Plant Sciences


The circadian clock in all organisms is usually considered to run with a period of 24 hours and have a fixed speed. My laboratory has discovered that sugars, nicotinamide and Ca2+ signals all can change the speed of the clock, some signals make it go faster and some make it go slower (Dodd et al., 2007 Science 318, 1789 - 1791; Dalchau et al., 2011 PNAS 108, 5104 – 5109; Marti et al., 2018 Nature Plants 4, 690-698). We have new data that suggest these changes in speed of the circadian oscillator contribute to the process by which plants know the time of day (Hearn et al., 2018 Plant Physiology 178, 358-371). We have now identified a large class of exciting new mutants that have lesions in the new signalling pathway that regulates the speed of the clock. You will these mutants to understand how the BIG protein regulates the speed of the circadian clock.



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