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Developmental Biology

Professor Ottoline Leyser
Director of the Sainsbury Laboratory Cambridge University

Professor Ottoline LeyserHormone signaling and the control of shoot branching

We are interested in how plants adapt their body plan to suit the environmental conditions in which they are growing. We are using the control of shoot branching in Arabidopsis as a model system to understand the regulatory systems that plants use to achieve this flexible development. Our main focus is on a network of hormonal signals that move between the root and shoot, allowing local and systemic information from the environment to be integrated to regulate branching. We would like to understand how the molecular events underlying the signalling and transport of these hormones supports flexible, environmentally sensitive patterns of branching in the whole plant.

hormones
click for larger image

Central to our work is the use of computational models of the actions and interactions of the hormonal network that regulates branching. The network includes multiple feedback loops making it difficult to predict its behaviour intuitively. Dynamical models of the system allow hypotheses to be tested in silico, generating predictions and identifying important parameters, which can then be used to guide wet lab experiments.

Linking molecular to whole plant level events with computational  modelling

branching - without text
From left: Branching in Arabidopsis plants grown with high (left) or low (right) nitrate supply. Centre: Computational model of branch production for plants with low (left) or high (right) levels of the hormone strigolactone. Green indicates auxin levels, and red indicates accumulation of PIN1 auxin transporters. Right: Accumulation of the PIN1 auxin transporter (green fluorescence) in cells of stems from plants with low (top) or high (bottom) strigolactone.

Contact:

Sainsbury Laboratory Cambridge
University of Cambridge
Bateman Street
Cambridge, CB2 1LR
Phone: 01223 761103
Email:
Website at the Sainsbury Laboratory