Dr Ian Henderson
Find out more about Ian Henderson or email Ian.Henderson@plantsci.cam.ac.uk
Project titles:
Project Title: Influence of epigenetic information on meiotic recombination
Supervisor: Dr Ian Henderson
Project outline:
Meiotic chromosomes pair and undergo homologous recombination, which has important consequences for patterns of natural variation and our ability to utilize it through breeding. Recombination patterns are highly non-random along chromosomes, though the mechanisms underlying these distributions are not well understood. The project will test the role of epigenetic information, including DNA methylation and small RNAs, on meiotic recombination patterns. The successful applicant will be trained to use a combination of genetics, genomics and cytology in Arabidopsis thaliana to address these questions.
References
- Henderson, I.R., and Jacobsen, S.E. Tandem repeats upstream of the Arabidopsis endogene SDC recruit non-CG DNA methylation and initiate siRNA spreading. Genes Dev. (2008) 22: 1597-1606. Henderson, I.R. and Jacobsen, S.E. Epigenetic inheritance in plants. Nature (2007) 447: 418-24.
See Research or
email: Ian.Henderson@plantsci.cam.ac.uk