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Dr Thomas Hardcastle

Senior Research Associate
Dr Thomas Hardcastle

Thomas Hardcastle is accepting applications for PhD students.

Thomas Hardcastle is available for consultancy.

Department of Plant Sciences
University of Cambridge
Downing Street

Cambridge CB2 3EA
Office Phone: 01223 748969

Research Interests

My research focuses on the development and application of computational tools in bioinformatics and especially tools for analysis of data from next-generation sequencing machines.

Key Publications

Hardcastle TJ, Kelly, KA. baySeq: Empirical Bayesian Methods For Identifying Differential Expression in Sequence Count Data. BMC Bioinformatics, 2010.

Molnar A, Melnyk CW, Bassett A, Hardcastle TJ, Dunn R, Baulcombe DC. Small Silencing RNAs in Plants Are Mobile and Direct Epigenetic Modification in Recipient Cells. Science, 2010.

Havecker ER, Wallbridge LM, Hardcastle TJ, Bush MS, Kelly KA, Dunn RM, Schwach F, Doonan JH, Baulcombe DC. The Arabidopsis RNA-Directed DNA Methylation Argonautes Functionally Diverge Based on Their Expression and Interaction with Target Loci. Plant Cell, 2010.

Cooke SL, Ng CKY, Melnyk N, Garcia MJ, Hardcastle TJ, Temple J, Langdon S, Huntsman D, Brenton JD. Genomic analysis of genetic hetrogeneity and evolution in high-grade serous ovarian carcinoma. Oncogene, 2010.

Djupedal I, Kos-Braun IC, Mosher RA, Söderholm N, Simmer F, Hardcastle TJ, Fender A, Heidrich N, Kagansky A, Bayne E, Wagner EG, Baulcombe DC, Allshire RC, Ekwall K. Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA. The EMBO Journal, 2009.

Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle TJ, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Chromosomal instability determines taxane response. PNAS, 2009.